C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C12N 15/00 (2006.01) C12N 15/12 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2659574
Disclosed are compositions and methods related to variable lymphocyte receptors (VLRs). More particularly, disclosed are a variety of antigen specific polypeptides, including soluble, monoclonal, and multivalent forms, as well as methods of using the polypeptides, antibodies that bind the antigen specific polypeptides, and nucleic acids, vectors and expression systems that encode the polypeptides. Antigen specific polypeptides that selectively bind pathogens, like anthrax, and carbohydrates, like blood group determinants, are specifically disclosed.
L'invention concerne des compositions et des procédés se rapportant à des récepteurs de lymphocytes variables (VLR). Plus particulièrement, l'invention concerne une diversité de polypeptides à spécificité antigénique, comprenant des formes solubles, monoclonales et multivalentes, ainsi que des procédés d'utilisation des polypeptides, des anticorps qui se lient aux peptides à spécificité antigénique, et des acides nucléiques, des vecteurs et des systèmes d'expression qui codent pour les polypeptides. L'invention concerne particulièrement des polypeptides à spécificité antigénique qui se lient de façon sélective aux pathogènes, tels que l'anthrax, et aux glucides, tels que des déterminants de groupe sanguin.
Alder Matthew N.
Cooper Max D.
Herrin Brantley R.
Marks & Clerk
The Uab Research Foundation
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