A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01) A61K 31/00 (2006.01) A61K 38/51 (2006.01)
Patent
CA 2614068
The invention relates to compositions and methods for the modulation of the permeability of the epithelial cell barrier complex. In particular, the invention provides compositions and methods for using polysaccharides, preferably glycosaminoglycans, and agents that modify cell surface glycosaminoglycans, preferably glycosaminoglycan-degrading enzymes to modulate intercellular junctions. The compositions and methods provided can be used to facilitate the delivery of biologically active molecules.
La présente invention a trait à des compositions et des procédés pour la modulation de la perméabilité du complexe barrière des cellules épithéliales. En particulier, l'invention a trait à des compositions et des procédés pour l'utilisation de polysaccharides, de préférence des glycosaminoglycannes, et des agents modificateurs de la surface cellulaire des glycosaminoglycannes, de préférence des enzymes de dégradation des glycosaminoglycannes pour la modulation de jonctions intercellulaires. Les compositions et les procédés de l'invention peuvent être utilisés pour faciliter l'administration de molécules biologiquement actives.
Berry David A.
Chandrasekaran Aarthi
Holley Kristine
Sasisekharan Ram
Sengupta Shiladitya
Massachusetts Institute Of Technology
Smart & Biggar
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