Methods and compositions related to thioesterase enzymes

Details Methods and compositions related to thioesterase enzymes Methods and compositions related to thioesterase enzymes

C - Chemistry, Metallurgy

10

L

C10L 1/02 (2006.01) C12N 9/16 (2006.01)

Patent

CA 2747516

The present invention relates to novel mutant thioesterase enzymes and naturally-occurring equivalents thereof, compositions made from such enzymes and uses of thioesterase enzymes. In particular, the present invention provides mutant thioesterase enzymes that have altered properties, for example, altered substrate specificity, altered activity, altered selectivity, and/or altered proportional yields in the product mixtures. The present invention also provides polynucleotides encoding such mutant thioesterase enzymes, and vectors and host cells comprising such polynucleotides. The invention further provides for novel uses of thioesterases in the production of various fatty acid derivatives, which are useful as, or as components of, industrial chemicals and fuels.

La présente invention concerne de nouvelles enzymes thioestérases mutantes et leurs équivalents apparaissant naturellement, des compositions faites à partir de telles enzymes et des usages d'enzymes thioestérases. En particulier, la présente invention permet d'obtenir des enzymes thioestérases qui ont des propriétés modifiées, par exemple, une spécificité de substrat modifiée, une activité modifiée, une sélectivité modifiée et/ou des gains proportionnels modifiés dans les mélanges de produits. La présente invention permet également d'obtenir des polynucléotides codant de telles enzymes thioestérases mutantes, et des cellules vecteurs et hôtes comprenant de tels polynucléotides. La présente invention concerne en outre des nouveaux usages de thioestérases dans la production de divers dérivés d'acides gras qui sont utiles en tant que combustibles et produits chimiques industriels ou composants de ceux-ci.

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