Methods and compositions relating to carcinoma stem cells

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C12N 5/095 (2010.01) A61K 31/7105 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01) C40B 30/04 (2006.01) C12N 15/113 (2010.01)

Patent

CA 2713469

MicroRNA markers of breast cancer stem cells (BCSC) are provided herein. The markers are polynucleotides that are differentially expressed in BCSC as compared to normal counterpart cells. Uses of the markers include use as targets for therapeutic intervention; as targets for drug development, and for diagnostic or prognostic methods relating to breast cancer and BCSC cell populations. BCSCs have the phenotype of having lower expression of certain miRNAs compared to normal breast epithelial cells, or to cancer cells that are not cancer stem cells.

L'invention porte sur des marqueurs microARN de cellules souches de cancer du sein (BCSC). Les marqueurs sont des polynucléotides qui sont exprimés de façon différentielle dans des BCSC par comparaison avec des cellules équivalentes normales. Les utilisations des marqueurs comprennent leur utilisation en tant que cibles pour une intervention thérapeutique ; en tant que cibles pour le développement de médicaments et pour des procédés de diagnostic ou de pronostic se rapportant au cancer du sein et aux populations de cellules BCSC. Les BCSC présentent le phénotype d'avoir une expression inférieure de certains ARNmi par comparaison avec des cellules épithéliales de sein normales ou avec des cellules cancéreuses qui ne sont pas des cellules souches cancéreuses.

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