C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/00 (2006.01) A61K 31/05 (2006.01) A61K 31/352 (2006.01) A61K 31/355 (2006.01) A61K 31/375 (2006.01) A61K 31/385 (2006.01) A61K 31/4045 (2006.01) A61K 35/12 (2006.01) A61K 38/06 (2006.01) A61K 38/17 (2006.01) A61K 38/44 (2006.01) A61K 38/45 (2006.01) A61K 39/395 (2006.01) A61K 41/00 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) A61P 39/06 (2006.01) C12Q 1/00 (2006.01) G01N 33/53 (2006.01) G01N 33/563 (2006.01) G01N 33/84 (2006.01) A61K 9/127 (2006.01) C12N 9/00 (2006.01) G01N 33/543 (2006.01)
Patent
CA 2422586
The invention relates generally to the field of immunology. More specifically, the invention relates the finding that antibodies can generate superoxide and hydrogen peroxide from singlet oxygen. Accordingly, methods and compositions able to increase or decrease oxidative stress are provided. Also provided are screening assays to identify agents that modulate the ability of a antibody to generate superoxide and hydrogen peroxide. Such agents can be used therapeutically to treat patients in need. Further, the invention provides methods to use antibodies in immunoassays.
L'invention concerne de manière générale le domaine de l'immunologie et plus spécifiquement la découverte que des anticorps peuvent produire du superoxyde et du peroxyde d'hydrogène à partir d'oxygène singulet. L'invention concerne en conséquence des procédés et des compositions appropriés permettant d'augmenter ou de réduire le stress oxydatif. L'invention concerne par ailleurs des tests sélectifs pour identifier des agents modulant l'aptitude d'un anticorps à produire du superoxyde et du peroxyde d'hydrogène. De tels agents s'utilisent à des fins thérapeutiques pour traiter des patients en conséquence. L'invention concerne en outre des procédés permettant d'utiliser des anticorps dans des immuno-essais.
Janda Kim D.
Jones Lyn H.
Lerner Richard A.
Wentworth Anita D.
Wentworth Paul
Gowling Lafleur Henderson Llp
The Scripps Research Institute
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