Methods and compositions relating to mek5 and cardiac...

Details Methods and compositions relating to mek5 and cardiac... Methods and compositions relating to mek5 and cardiac...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A01K 67/027 (2006.01) A61K 35/76 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 45/06 (2006.01) A61K 48/00 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 25/02 (2006.01) A61P 43/00 (2006.01) C12N 15/09 (2006.01) C12N 15/861 (2006.01) C12N 15/863 (2006.01) C12N 15/867 (2006.01) C12N 15/869 (2006.01) C12Q 1/02 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50

Patent

CA 2384907

The present invention relates to compositions and methods relating to MEK5 and its role in heart disease. This protein has now been identified as a target for therapeutic intervention due to its role molecular events that lead to or contribute to cardiac hypertrophy and/or dilated cardiomyopathy. In particular, inhibition of MEK5 activity will lead to decrease signalling of the pathways and reduce or eliminate the effects on sarcomere assembly, which in turn result or contribute to cardiac dysfunction. Also provided are transgenic animals and methods of screening for inhibitors of MEK5.

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