Methods and compositions relating to pancreatic islet and...

G - Physics – 01 – N

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G01N 33/50 (2006.01) C07K 14/47 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2377752

Methods and compositions relating to pancreatic islet and .beta.-cell dysfunction, in conditions such as non-insulin dependent diabetes, are disclosed. Specifically, proteins that are differentially expressed in these conditions are identified. In one aspect, the invention provides a method of screening an agent to determine its usefulness in treating a condition characterised by pancreatic islet or .beta.-cell dysfunction, based on establishing a paradigm in which at least one protein is differentially expressed in relevant tissue from, or representative of, subjects having differential levels of pancreatic islet or .beta.-cell function.

L'invention concerne des procédés et des compositions se rapportant à la dysfonctions des îlots pancréatiques et des cellules .beta., dans les pathologies telles que le diabète non insulino-dépendant. L'invention concerne en particulier des protéines exprimées de manière différentielle dans ces pathologies. Un des aspects de l'invention concerne un procédé de criblage permettant de déterminer l'efficacité d'un agent dans le traitement d'une pathologie caractérisée par une dysfonction des îlots pancréatiques ou des cellules .beta.. Ce procédé repose sur l'établissement d'un paradigme dans lequel au moins une protéine est exprimée de manière différentielle dans le tissu concerné prélevé sur des sujets ou représentatif de sujets chez lesquels la fonction des îlots pancréatiques ou des cellules .beta. présente des niveaux modifiés.

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