C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/02 (2006.01) A61K 39/40 (2006.01) C07K 9/00 (2006.01) C07K 14/21 (2006.01) C07K 16/12 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12P 21/08 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2115565
The present disclosure relates to selected antigenic proteins obtained from the outer membranes of Moraxella catarrhalis, that are found to have a variety of useful properties. These proteins, termed OMPs ("Outer Membrane Proteins"), are character-ized as having molecular weights of about 30 kD, 80kD and between about 200 and 700 kD, respectively. Studies set forth herein demonstrate that monoclonal antibodies directed against these proteins confer a protective effect against infection by Moraxella catarrhalis organisms in animal models, demonstrating the potential usefulness of such antibodies in conferring passive immuni-ty as well as the potential usefulness of these OMPs, or variants thereof, in the preparation of vaccines. Also disclosed are DNA segments encoding these OMPs, methods for preparing the antigens, or variants, through the application of recombinant DNA techniques, as well as diagnostic methods and embodiments.
Hansen Eric J.
Helminen Merja
Maciver Isobel
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Board Of Regents The University Of Texas System
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