Methods and compositions to determine the chemosensitizing...

Details Methods and compositions to determine the chemosensitizing... Methods and compositions to determine the chemosensitizing...

A - Human Necessities

61

K

A61K 31/17 (2006.01) A61K 31/185 (2006.01) A61K 31/282 (2006.01) A61K 31/335 (2006.01) A61K 31/337 (2006.01) A61K 33/24 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2461227

A method for determining a therapeutically effective amount of suramin for administering to a patient, who is to receive a cytotoxic agent, which comprises the steps of determining the circulating suramin concentration in the patient; administering suramin, if required, to establish a low circulating concentration of suramin in the patient of below about 200 ~M; and administering the chemotherapeutic agent to the patient when the low circulating concentration of suramin is present in the patient. Conveniently a nomogram can be constructed for use in clinical settings with the suramin.

L'invention concerne un procédé permettant de déterminer une quantité efficace sur le plan thérapeutique de suramine à administrer à un patient, lequel reçoit un agent cytotoxique. Ce procédé comprend les étapes consistant à déterminer la concentration de suramine en circulation chez le patient ; à administrer de la suramine, si nécessaire, de manière à établir une faible concentration en circulation de suramine chez le patient, la concentration étant inférieure à environ 200 µM; et à administrer l'agent chimiothérapeutique au patient quand la faible concentration en circulation de suramine est présente chez le patient. De manière pratique, un nomogramme peut être construit aux fins d'utilisation dans des conditions cliniques avec la suramine.

Affiliated with

Also associated with

Rating

Methods and compositions to determine the chemosensitizing... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions to determine the chemosensitizing..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions to determine the chemosensitizing... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1946467