C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/435 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2612516
The present invention provides a method of treating cancer by providing to a subject in need thereof an immunogenic composition comprising a nucleic acid construct encoding a polypeptide comprising CTL epitopes PSMA288-297 and PRAME425-433, or a cross-reactive analogue. In embodiments of the present invention there is provided methods and compositions for inducing, entraining, and/or amplifying the immune response to MHC class-I restricted epitopes of carcinoma antigens to generate an effective anti-cancer immune response.
La présente invention concerne une méthode destinée au traitement du cancer, consistant à fournir à un sujet nécessitant un tel traitement une composition immunogène comprenant un acide nucléique hybride codant pour un polypeptide comprenant des épitopes CTL PSMA288-297 et PRAME425-433, ou un analogue à réaction croisée. Des modes de réalisation de la présente invention concernent des méthodes et des compositions permettant d'induire, de provoquer et/ou d'amplifier la réponse immunitaire aux épitopes restreints par des molécules du complexe majeur d'histocompatibilité de classe I d'antigènes tumoraux pour produire une réponse immunitaire anticancéreuse efficace.
Bot Adrian
Qiu Zhiyong
Mannkind Corporation
Perry + Currier
LandOfFree
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