Methods and compositions using adiponectin for treatment of...

Details Methods and compositions using adiponectin for treatment of... Methods and compositions using adiponectin for treatment of...

A - Human Necessities

61

K

A61K 39/00 (2006.01) A01N 43/04 (2006.01) A61K 31/70 (2006.01)

Patent

CA 2542142

We have surprisingly discovered that adiponectin regulates angiogenesis and have shown that adiponectin is an effective agent at treating cardiac disorders. As a result of this discovery, the present invention provides methods for treatment of cardiac disorders and methods for stimulation of angiogenesis in tissues using adiponectin. In one preferred embodiment, the methods of the invention are used to treat complications of diabetes, such as ischemic limbs and hypertrophic cardiomyopathy.

On a découvert de manière tout à fait surprenante que l'adiponectine effectue une régulation de l'angiogenèse et on a démontré que l'adiponectine est un agent efficace pour le traitement de troubles cardiaques. Suite à cette découverte, la présente invention a trait à des procédés pour le traitement de troubles cardiaques et des procédés pour la stimulation de l'angiogenèse dans des tissus au moyen d'adiponectine. Dans un mode de réalisation préféré, les procédés de l'invention sont mis en oeuvre pour le traitement de complications du diabète, telles que des membres ischémiques ou la cardiomyopathie hypertrophique.

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