Methods and compositions using butyrate esters of threitol

Details Methods and compositions using butyrate esters of threitol Methods and compositions using butyrate esters of threitol

A - Human Necessities

61

K

A61K 31/22 (2006.01)

Patent

CA 2235603

The present invention relates to the use of butyrate esters of threitol, alone or in combination with other agents, in pharmaceutical compositions and methods for increasing fetal hemoglobin and gamma globin in a patient. These methods are particularly useful in treating .beta.-hemoglobinopathies, such as sickle cell syndromes and .beta.-thalassemia syndromes. Compositions comprising butyrate esters of threitol, alone or in combination antiproliferative and differentiating agents are also useful in methods for inducing cell differentiation in malignant cells. These methods are useful in treating cancer, particularly the tetrabutyrate ester.

Cette invention, qui porte sur l'utilisation d'esters butyriques de thréitol, seuls ou en association avec d'autres agents, dans des compositions pharmaceutiques, concerne également des techniques permettant d'accroître chez un patient les concentrations en hémoglobine foetale et en gamma globine. Ces techniques s'avèrent des plus utiles pour le traitement d'hémoglobinopathies-.beta., les syndromes de falciformation et de thalassémie-.beta., par exemple. Des compositions comportant des esters butyriques de thréitol, seuls ou en association avec des agents antiprolifératifs et de différenciation, se révèlent également efficaces dans le cadre de procédés visant à déclencher une différenciation cellulaire dans des cellules malignes. Ces techniques sont utiles pour le traitement de cancers, notamment celles qui font intervenir un ester tétrabutyrique.

Affiliated with

Also associated with

Rating

Methods and compositions using butyrate esters of threitol does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Methods and compositions using butyrate esters of threitol, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and compositions using butyrate esters of threitol will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1824699