A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/165 (2006.01) A61K 31/17 (2006.01) A61K 31/19 (2006.01) A61K 31/454 (2006.01) A61P 7/06 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01)
Patent
CA 2652888
Provided herein are compositions comprising one or more immunomodulatory compounds and valproic acid, hydroxyurea or trichostatin A, methods for their use in CD34+ hematopoietic stem cell expansion in vitro and in vivo for bone marrow reconstitution and bone marrow transplantation, increasing fetal hemoglobin expression, and methods for treating, preventing and/or managing cancer, tumors and hematological diseases and disorders.
L'invention concerne des compositions comprenant un ou plusieurs composés immunomodulateurs et de l'acide valproïque, de l'hydroxyurée ou de la trichostatine A, des méthodes d'utilisation desdites compositions pour l'expansion de cellules souches hématopoïétiques CD34+ in vitro et in vivo pour la reconstitution de moelle osseuse et la greffe de moelle osseuse, pour l'augmentation de l'expression d'hémoglobine fétale, ainsi que des méthodes de traitement, de prévention et/ou de gestion du cancer, de tumeurs et de maladies et troubles hématologiques.
Brady Helen
Chan Kyle
Corral Laura
Moutouh de Parseval Laure
Verhelle Dominique
Celgene Corporation
Smart & Biggar
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