Methods and compositions utilizing rad51

Details Methods and compositions utilizing rad51 Methods and compositions utilizing rad51

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 31/40 (2006.01) A61K 31/4184 (2006.01) A61K 31/7084 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2384733

Herein methods are provided for determining the distribution of Rad51 foci in a first tissue type of a first individual, and then comparing the distribution to the distribution of Rad51 foci from a second normal tissue type from the first individual or a second unaffected individual. A difference in the distributions indicates that the first individual is at risk for a disease state which results in aberrant Rad51 foci. Preferred disease states include cancer and disease states associated with apoptosis. Also provided herein are methods for screening for modulators of Rad51 or homologues thereof and methods of using modulators of Rad51.

Cette invention concerne des techniques servant à déterminer la répartition de foyer de Rad51 dans un premier type de tissu d'un premier individu, puis à comparer cette distribution à la distribution de foyers de Rad51 dans un second type de tissu normal prélevé sur le premier individu ou sur un second individu sain. Tout écart de répartition indique que le premier individu est menacé par une affection qui se traduit par des foyers aberrants de Rad51. Ces affections sont de préférence des cancers ou des états pathologiques en rapport avec une apoptose. L'invention concerne également des techniques de recherche systématique de modulateurs de Rad51 ou d'homologue de Rad51 et des méthodes d'utilisation de ces modulateurs.

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