Methods and compositions with enhanced therapeutic activity

Details Methods and compositions with enhanced therapeutic activity Methods and compositions with enhanced therapeutic activity

A - Human Necessities

61

K

A61K 39/395 (2006.01)

Patent

CA 2614046

The properties of an Fc-containing protein, for example, an antibody, are controlled by altering the sialylation of the oligosaccharides in the Fc region. The modified Fc-containing proteins have therapeutic utility in diseases or conditions in which it is desirable to control the affinity for one or more of the FcgRI, FcgRIIA, and FcgRIIIA receptors, ADCC activity, macrophage or monocyte activation, serum half-life, and avidity.

Les propriétés d'une protéine contenant un Fc, par exemple, un anticorps, sont maîtrisées par modification de la sialylation des oligosaccharides dans la région Fc. Le protéines contenant le Fc modifié présentent une utilité thérapeutique dans les maladies ou les états pathologiques où il est souhaitable de maîtriser l'affinité pour au moins l'un des récepteurs FcgRI, FcgRIIA, et FcgRIIIA, l'activité ADCC, l'activation des macrophages ou monocytes, la demi-vie sérique, ainsi que l'avidité.

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