C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) A01K 67/00 (2006.01) A01K 67/027 (2006.01) A01K 67/033 (2006.01) A01N 37/18 (2006.01) A01N 43/04 (2006.01) A61K 31/7105 (2006.01) A61K 38/17 (2006.01) A61K 38/43 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) G01N 33/50 (2006.01) G01N 33/567 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2467919
The subject invention provides methods of treating amyloidogenic diseases, comprising the administration of therapeutically effective amounts of a composition comprising a carrier and an agent that interferes with the interaction of CD40L and CD40R to an individual afflicted with a amyloidogenic disease. Also provided are methods and/or assay systems for the identification of compounds or other small molecules capable of disrupting the CD40R/CD40L signaling pathway.
L'invention concerne des méthodes de traitement de maladies amyloïdogéniques, comprenant l'administration de quantités efficaces au niveau thérapeutique d'une composition comprenant un excipient et un agent qui interfère dans l'interaction de CD40L et CD40R chez un individu souffrant d'une maladie amyloïdogénique. L'invention concerne également des procédés et/ou systèmes d'analyse pour l'identification de composés ou d'autres petits molécules pouvant fragmenter la voie de signalisation de CD40R/CD40L.
Mullan Michael
Tan Jun
Town Terrence C.
Ridout & Maybee Llp
Roskamp Research Llc
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