Methods and compounds for inhibiting amyloid deposits

Details Methods and compounds for inhibiting amyloid deposits Methods and compounds for inhibiting amyloid deposits

A - Human Necessities

61

K

A61K 31/472 (2006.01) A61K 31/47 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2373093

Methods and compositions which are useful in the treatment of amyloidosis. In particular, methods and compositions are provided for inhibiting, preventing and treating amyloid deposition, e.g., in pancreatic islets, wherein the amyloidotic deposits are islet amyloid polypeptide (IAPP)-associated amyloid deposition or deposits. The methods of the invention involve administering to a subject a therapeutic compound which inhibits IAPP-associated amyloid deposits. Accordingly, the compositions and methods of the invention are useful for inhibiting IAPP-associated amyloidosis in disorders in which such amyloid deposition occurs, such as diabetes.

L'invention concerne des procédés et des compositions utiles dans le traitement de l'amylose. L'invention concerne en particulier des procédés et des compositions utiles pour l'inhibition, la prévention et le traitement des dépôts amyloïdes, par exemple dans les îlots pancréatiques, lesdits dépôts étant alors des dépôts amyloïdes associés aux polypeptides amyloïdes des îlots. Les procédés décrits consistent à administrer au sujet un composé thérapeutique inhibant les dépôts amyloïdes associés aux polypeptides amyloïdes des îlots. Les compositions et les procédés considérés sont donc utiles pour inhiber les dépôts amyloïdes associés aux polypeptides amyloïdes des îlots dans les troubles qui sont caractérisés par ce type d'amylose, comme le diabète.

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