Methods and compounds for inhibiting the cytokine or...

Details Methods and compounds for inhibiting the cytokine or... Methods and compounds for inhibiting the cytokine or...

C - Chemistry, Metallurgy

07

D

C07D 235/26 (2006.01) A61K 31/4184 (2006.01) A61K 31/585 (2006.01) C07C 43/225 (2006.01) C07C 43/23 (2006.01) C07C 45/00 (2006.01) C07C 45/46 (2006.01) C07C 59/58 (2006.01) C07C 65/24 (2006.01) C07C 65/28 (2006.01) C07C 69/94 (2006.01) C07C 205/59 (2006.01) C07C 229/70 (2006.01) C07C 255/37 (2006.01) C07C 309/60 (2006.01) C07C 309/75 (2006.01) C07C 333/04 (2006.01) C07D 235/28 (2006.01) C07D 307/83 (2006.01) C07D 319/18 (2006.01) C07D 403/12 (2006.01) C07H 13/10 (2006.01)

Patent

CA 2487838

Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) as defined herein, is provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as part of a combination therapy. Novel heterocyclic compounds are also provided for.

Procédé visant à inhiber l'activité des cytokines ou l'activité biologique du facteur d'inhibition de la migration des macrophages (MIF), qui comporte l'étape consistant à mettre en contact le MIF avec un composé représenté par la formule (I), telle que définie dans la demande. L'invention concerne aussi des méthodes de traitement de maladies ou d'états pathologiques impliquant l'activité des cytokines ou l'activité biologique du MIF, ces méthodes comprenant l'administration de composés représentés par la formule (I), soit seuls ou en thérapie combinée. L'invention concerne également de nouveaux composés hétérocycliques.

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