Methods and compounds for prevention of graft rejection

Details Methods and compounds for prevention of graft rejection Methods and compounds for prevention of graft rejection

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/495 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01) C12N 5/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2130802

2130802 9317043 PCTABS00025 Disclosed is a method of preventing graft rejection by inducing a state of local immunosuppression at the transplant site with expression of recombinant proteins by the allograft. Also disclosed is a protein suppressor factor that is secreted by cloned anergic T-cells, blocks interleukin 2 (IL-2) stimulated T-cell proliferation, has an apparent molecular weight of between 10 and 30 kilodaltons, can be inactivated by heating to 65 ·C for 15 minutes, blocks interleukin 4 (IL-4) stimulated T-cell proliferation in vitro), is non-cytotoxic to T-cells, and does not inhibit the production of IL-2 by T-cells in vitro.

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