Methods and compounds for the targeting of protein to exosomes

Details Methods and compounds for the targeting of protein to exosomes Methods and compounds for the targeting of protein to exosomes

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 9/127 (2006.01) A61K 31/7088 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01) C07K 14/55 (2006.01) C07K 19/00 (2006.01) C12N 5/00 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01) C12Q 1/02 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2454756

The present invention relates to compositions and methods for selectively expressing a polypeptide in a membrane vesicle. The invention also relates to genetic constructs and recombinant cells suitable to produce such membrane vesicles. This invention also relates to such functionalized membrane vesicles as well as to methods of making antibodies, methods of producing or regulating an immune response as well as to methods of screening or identifying binding partners using the same. The invention more particularly uses lactadherin or portions thereof to selectively express polypeptides in membrane vesicles, of natural or synthetic origin. This invention can be used in experimental, research, therapeutic, prophylactic or diagnostic areas.

L'invention concerne des composés et des procédés pour l'expression sélective d'un polypeptide dans une vésicule membranaire, ainsi que des constructions génétiques et des cellules recombinées pouvant produire de telles vésicules membranaires. La présente invention porte également sur ces vésicules membranaires fonctionnalisées et sur des procédés pour créer des anticorps, pour produire ou réguler une réponse immunitaire, et pour cribler ou identifier des partenaires de liaison associés. Cette invention fait plus particulièrement appel à la lactadhérine ou à des parties de celle-ci pour l'expression sélective de polypeptides dans des vésicules membranaires, d'origine naturelle ou synthétique. Ladite invention peut être appliquée dans le secteur expérimental, la recherche, les domaines thérapeutique ou prophylactique et le diagnostic.

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