Methods and computer program products for analysis and...

G - Physics – 01 – N

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G01N 21/84 (2006.01) G06F 19/18 (2011.01) G01N 15/00 (2006.01) G01N 33/52 (2006.01)

Patent

CA 2580937

Methods and computer program products for evaluating and optimizing one or more markers for use in establishing a prognosis for a patient suffering from a disease are provided. More particularly, the methods include steps for systematically evaluating a number of features that may be extracted from an image of a body sample, such as a histological slide, that has been exposed to one or more biomarkers so as to establish a prognostic decision rule based on one or more of the extracted features such that the decision rule yields a prognosis that is optimally predictive of actual patient outcome. Thus, the methods and computer program products provided yield optimally predictive prognoses to assist clinicians in developing strategies for effective patient care management.

L'invention concerne des procédés et des produits logiciels permettant d'évaluer et d'optimiser un ou plusieurs marqueurs à utiliser dans l'établissement d'un pronostic pour un patient souffrant d'une maladie. Plus particulièrement, les procédés comprennent des étapes permettant d'évaluer de manière systématique un certain nombre de caractéristiques pouvant être extraites d'une image d'un échantillon corporel, de type lame histologique, ayant été exposée à un ou à plusieurs marqueurs biologiques afin que soit établie une règle de décision pronostique fondée sur une ou plusieurs des caractéristiques de façon que la règle de décision permette d'établir un pronostic qui prédit de manière optimale l'évaluation de l'état de santé réelle d'un patient. Les procédés et produits logiciels de l'invention permettent ainsi d'établir des pronostics prédictifs pour aider des médecins à développer des stratégies pour une gestion efficace de la santé d'un patient.

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