Methods and contrast agents useful in quantifying nitric oxide

Details Methods and contrast agents useful in quantifying nitric oxide Methods and contrast agents useful in quantifying nitric oxide

A - Human Necessities

61

K

A61K 49/06 (2006.01) A61K 49/10 (2006.01)

Patent

CA 2490285

A contrast agent for nuclear magnetic resonance spectroscopy adapted for use in a living tissue comprising at least one reporter nucleus, together with a pharmaceutically acceptable carrier is disclosed. The contrast agent exhibits a first spectral property when not bound by nitric oxide, and a second spectral property when bound by nitric oxide. Methods of using the contrast agents for the detection of nitric oxide are also disclosed.

Cette invention, qui a trait à un agent de contraste utilisable en spectroscopie par résonance magnétique nucléaire prévu pour être utilisé avec un tissu vivant et comportant au moins un noyau rapporteur, concerne également un excipient acceptable du point de vue pharmaceutique. Cet agent de contraste fait montre d'une première propriété spectrale lorsqu'il n'est pas lié à de l'oxyde nitrique et d'une seconde lorsqu'il est lié à celui-ci. L'invention porte, en outre, sur des méthodes d'utilisation des agents de contraste aux fins de la détection d'oxyde nitrique.

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