C - Chemistry – Metallurgy – 12 – M
Patent
C - Chemistry, Metallurgy
12
M
C12M 3/00 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2538440
The present invention relates to methods and devices for adhering cells in a specific and predetermined position with an adhesive control of internal cell organisation, methods for preparing such devices, methods for studying modifications of cell shape and global internal cell organization such as the distribution of cellular compartments, centrosome centering, spindle orientation, internal compartimentalization and internal transports, methods for screening compounds of interest which enhance or inhibit specific cell functions.
La présente invention concerne des méthodes et des dispositifs permettant l'adhérence des cellules dans une position précise et prédéterminée, à l'aide d'une régulation par adhérence de l'organisation cellulaire interne, des méthodes pour préparer de tels dispositifs, des méthodes pour étudier des modifications de la forme cellulaire et de l'organisation cellulaire interne globale, par exemple la répartition des compartiments cellulaires, le centrage des centrosomes, l'orientation du fuseau, la compartimentalisation interne et les transports internes, ainsi que des méthodes pour le criblage de composés d'intérêt qui stimulent ou inhibent des fonctions cellulaires spécifiques.
Bornens Michel
Piel Matthieu
Thery Manuel
Centre National de La Recherche Scientifique
Institut Curie
Robic
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