A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61B 17/20 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 39/35 (2006.01) C07K 14/11 (2006.01) G01M 5/00 (2006.01) G01N 33/50 (2006.01) G01N 33/564 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2204253
The invention is directed to methods for introducing biologically active peptides into a host by administration of polynucleotides which operatively encode for the peptide of interest. In a preferred embodiment of the invention, a mammal is desensitized to an antigen, in particular an allergen, through administration to the mammal of polynucleotides which operatively encode the antigen. The antigen-encoding polynucleotides are administered to host tissues which have a high concentration of antigen presenting cells in them relative to other host tissues. The method is particularly useful in treating allergies because the allergen-encoding polynucleotides of the invention to induce tolerance while suppressing IgE antibody formation. Devices and compositions for use in the methods of the invention are also described.
Procédés d'introduction de peptides biologiquement actifs dans un hôte par administration de polynucléotides modifiés à dessein qui codent pour le peptide d'intérêt. Dans l'une des variantes préférées de l'invention, un mammifère est désensibilisé à un antigène, en particulier à un allergène, par administration de polynucléotides modifiés à dessein qui codent pour l'antigène. Lesdits polynucléotides sont administrés aux tissus hôtes présentant une plus forte concentration en cellules contenant des antigènes que les autres tissus hôtes. Le procédé s'avère particulièrement utile dans le traitement des allergies puisque lesdits polypeptides provoquent la tolérance en supprimant la formation des anticorps de l'IgE. Des équipements et préparations relatifs à ces procédés sont également présentés.
Carson Dennis A.
Howell Meredith L.
Raz Eyal
Mbm Intellectual Property Law Llp
The Regents Of The University Of California
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