C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) A61P 37/02 (2006.01) C12N 15/62 (2006.01) C12N 15/74 (2006.01)
Patent
CA 2668984
The present invention relates to the field of peptide delivery for the treatment of non-Helicobacter associated disease, wherein the peptide is delivered at the mucosa in vivo. In particular, the present invention relates to a method for delivering peptides to the mucosal of an animal in need thereof comprising the steps of: i) inserting a gene encoding a peptide into the gene encoding the urease enzyme of Helicobacter pylori to produce an in-frame gene so that the urease enzyme function is not impaired when the in-frame gene is expressed; and ii) infecting said animal such that the Helicobacter pylori colonises the mucosa.
La présente invention concerne le domaine de l'administration de peptides pour le traitement d'une maladie non associée à Helicobacter, le peptide étant administré à la muqueuse in vivo. En particulier, la présente invention concerne un procédé permettant d'administrer les peptides à la muqueuse d'un animal ayant besoin de ceux-ci, qui comprend les étapes consistant à : i) insérer un gène codant pour un peptide dans le gène codant pour l'enzyme uréase de Helicobacter pylori pour produire un gène in situ, de telle sorte que la fonction de l'enzyme uréase n'est pas altérée lorsque le gène in situ est exprimé ; et ii) infecter ledit animal, de telle sorte que Helicobacter pylori colonise la muqueuse.
Borden Ladner Gervais Llp
Marshall Barry J.
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