Methods and devices for the removal of psoralens from blood...

C - Chemistry – Metallurgy – 12 – M

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C12M 1/12 (2006.01) A61K 35/14 (2006.01) A61L 2/00 (2006.01) A61L 2/10 (2006.01) A61L 2/18 (2006.01) A61M 1/36 (2006.01) C12N 7/06 (2006.01)

Patent

CA 2221605

Methods and devices for the removal of psoralens and psoralen photoproducts from blood products are described. The methods include contacting a psoralen- and irradiation-treated blood product with a resin capable of adsorbing psoralens and psoralen photoproducts. The removal process is particularly suitable for use with platelet concentrates and plasma because the process does not have a significant adverse effect on clotting factor function. The methods and devices can be incorporated with apheresis systems and other devices and procedures currently used to process blood products for transfusion.

Procédés et dispositifs d'extraction des psoralènes et des photoproduits créés par les psoralènes dans les produits sanguins. Le procédé consiste à mettre un produit sanguin traité par psoralènes et irradiation en contact avec une résine capable d'adsorption des psoralènes et des photoproduits créés par les psoralènes. Le processus d'extraction est particulièrement adapté à l'utilisation avec des concentrés de plaquettes et du plasma, dans la mesure où le procédé n'a pas d'effet indésirable notable sur la fonction du facteur de coagulation. Les procédés et dispositifs décrits peuvent être intégrés à des systèmes d'aphérèse et dans d'autres dispositifs et procédés actuellement utilisés pour traiter les produits sanguins pour la transfusion.

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