Methods and devices for the treatment of intervertebral discs

A - Human Necessities – 61 – L

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A61L 27/00 (2006.01) A61F 2/44 (2006.01) A61L 31/00 (2006.01)

Patent

CA 2534983

Devices for the treatment of intervertebral discs are described. The devices, when implanted into the nucleus pulposus of an intervertebral disc, provide for the controlled release of one or more active agents into the disc. The active agent can be a chemonucleolytic agent such as chymopapain. The device can also comprise one or more binders. The device can be an elongate solid body having a tapered or rounded insertion end. Alternatively, the device can include a plurality of particles. For devices containing multiple active agents, the configuration of the device be chosen to provide for the sequential or simultaneous release of each of the active agents. The elongate solid body can include a sheath comprising a first active agent and a core comprising a second active agent. Methods of making the devices and methods of treatment comprising implanting the devices into an intervertebral disc are also described.

L'invention concerne des dispositifs de traitement des disques intervertébraux. Ces dispositifs offrent une libération contrôlée d'un ou plusieurs agents actifs dans les disques lorsqu'ils sont implantés dans le noyau gélatineux d'un disque intervertébral. L'agent actif peut être un agent chimionucléolytique, tel que de la chymopapaïne. Le dispositif comprend également un ou plusieurs liants. Il peut consister en un corps solide de forme allongée possédant une extrémité d'insertion tronconique ou arrondie. Dans un autre mode de réalisation, le dispositif peut comprendre plusieurs particules. Pour les dispositifs contenant plusieurs agents actifs, la configuration du dispositif est choisie de manière à offrir une libération séquentielle ou simultanée de chacun des agents actifs. Le corps solide de forme allongée peut comprendre une gaine contenant un premier agent actif et un noyau contenant un second agent actif. Des procédés de fabrication de ces dispositifs et des procédés de traitement consistant à implanter les dispositifs dans un disque intervertébral sont également décrits.

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