Methods and devices for tissue repair

Details Methods and devices for tissue repair Methods and devices for tissue repair

A - Human Necessities

61

K

A61K 35/32 (2006.01) A61K 35/28 (2006.01) A61K 35/48 (2006.01) A61L 27/38 (2006.01) A61L 27/40 (2006.01) A61L 27/52 (2006.01) A61P 19/00 (2006.01) C12N 11/00 (2006.01) C12N 5/071 (2010.01) C12N 5/077 (2010.01)

Patent

CA 2437212

Methods for treating diseased or damaged tissue in a subject are disclosed, involving administering to said subject at a site wherein diseased or damaged tissue occurs, cells of a type(s) normally found in healthy tissue corresponding to the diseased or damaged tissue, and/or suitable progenitor cells thereof, in association with bioresorbable beads or particles and optionally a gel and/or gel-forming substance. Where the cells and/or suitable progenitor cells thereof are chondrocytes, embryonic stem cells and/or bone marrow stromal cells, the methods of the invention are suitable for treating, for example, articular cartilage degeneration associated with primary osteoarthritis. Also disclosed is a device having tissue-like characteristics for treating diseased or damaged tissue in a subject, wherein the device comprises cells of a type(s) normally found in healthy tissue corresponding to the diseased or damaged tissue, and/or suitable progenitor cells thereof, in association with bioresorbable beads or particles and optionally a gel and/or gel-forming substance.

L'invention concerne des méthodes de traitement de tissus malades ou endommagés chez un sujet, consistant à administrer au sujet, sur le site où se trouvent les tissus malades ou endommagés, des cellules du type de celles normalement contenues dans un tissu sain correspondant au tissu malade ou endommagé, et/ou des cellules précurseurs de celles-ci, en association avec des perles ou particules biodégradables et, éventuellement, un gel et/ou une substance formant un gel. Lorsque les cellules et/ou les cellules précurseurs adaptées de celles-ci sont des chondrocytes, des cellules souches embryoniques et/ou des cellules stromales médullaires, les méthodes de l'invention sont adaptées pour traiter, par exemple, la dégénération du cartilage articulaire associée à l'ostéoarthrite primaire. L'invention concerne également un dispositif présentant des caractéristiques de type tissulaire servant à traiter un tissu malade ou endommagé chez un sujet, ledit dispositif comprenant des cellules du type de celles normalement contenues dans un tissu sain correspondant au tissu malade ou endommagé, et/ou des cellules précurseurs de celles-ci, en association avec des perles ou des particules biodégradables et éventuellement un gel et/ou une substance formant un gel.

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