Methods and dosage forms for controlled delivery of oxycodone

A - Human Necessities – 61 – K

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A61K 9/22 (2006.01) A61K 9/00 (2006.01) A61K 31/485 (2006.01) A61P 25/04 (2006.01)

Patent

CA 2483655

Dosage forms and methods for the controlled release of oxycodone over a prolonged period of time are described. The sustained release dosage forms provide therapeutically effective average steady-state plasma oxycodone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma oxycodone concentration occurrence in each 24 hour period that occurs at a later time after administration and exhibits a lesser magnitude than the peak plasma oxycodone concentration that occurs following administration of oxycodone in an immediate-release dosage form and other prior art extended release dosage forms.

La présente invention concerne des formes dosifiées et des procédés permettant la libération contrôlée d'oxycodone pendant sur une longue période. Les formes dosifiées à libération prolongée, lorsqu'elles sont administrées une fois par jour, fournissent des concentrations moyennes thérapeutiquement efficaces d'oxycodone dans le plasma à l'état stabilisé. Cette administration de la dose posologique une fois par jour aboutit à une pointe unique de la concentration de l'oxycodone dans le plasma par période de 24 heures, survenant après l'administration. En outre, cette pointe est moins grande que celle qui survient après administration d'oxycodone dans une forme dosifiée à libération immédiate et les autres formes dosifiées à libération prolongée selon l'état actuel de la technique.

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