Methods and formulations for use in inhibiting conception...

A - Human Necessities – 61 – K

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A61K 38/09 (2006.01) A61K 31/56 (2006.01) A61K 9/00 (2006.01) A61K 9/16 (2006.01)

Patent

CA 2084891

Compositions and methods which are effective to inhibit conception and to treat benign gynecological disorders for extended periods of time are described, wherein an effective amount of a gonadotropin hormone releasing hormone composition and an effective amount of an estrogenic composition are provided over a first period of time, in addition to a progestogen and optionally an androgenic composition. According to one protocol, the progestogen is provided for a second, shorter period of time; the progestogen is provided at a higher level for at least 5 to about 20 days, and then at a lower level for the remainder, if any, of the second period of time. In an alternative, protocol, the progestogen is provided at a lower level substantially throughout the period of administration of gonadotropin hormone releasing hormone composition and estrogenic composition. An effective amount of the androgenic hormone is optionally provided over the first period of time.

Compositions et procédés efficaces pour la contraception et pour le traitement de troubles gynécologiques bénins pendant des périodes prolongées. Une quantité efficace d'une composition hormonale libérant l'hormone de gonadotropine et une quantité efficace d'une composition oestrogène sont administrées pendant une première période de temps, en plus d'une composition progestogène et éventuellement androgène. Selon un protocole, la progestogène est administrée pendant une seconde période de temps plus courte; la progestogène est administrée à un niveau plus élevé pendant au moins 5 à 20 jours environ puis, s'il y a lieu, à un niveau plus faible pendant le reste de la seconde période de temps. Selon une variante du protocole, la progestogène est administrée à un niveau plus faible pratiquement toute la période d'administration de la composition hormonale de libération de l'hormone gonadotropine et de la composition oestrogène. Une quantité efficace de l'hormone androgène est éventuellement administrée pendant la première période de temps.

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