A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A01N 43/04 (2006.01) A61K 31/70 (2006.01) A61K 31/715 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01)
Patent
CA 2507249
This invention relates to methods and compositions for treating or preventing disease comprising the administration of immune modulatory nucleic acids having one or more immune modulatory sequences (IMSs). The invention further relates to the means and methods for the identification of the IMSs for preventing or treating disease, more particularly the treatment and prevention of autoimmune or inflammatory diseases. The invention also relates to the treatment or prevention of disease comprising the administration of the immune modulatory nucleic acids alone or in combination with a polynucleotide encoding self-protein(s), -polypeptide(s) or -peptide(s). The present invention also relates to methods and compositions for treating diseases in a subject associated with one or more self-protein(s), -polypeptide(s) or - peptide(s) that are present in the subject and involved in a non-physiological state.
L'invention porte sur des procédés et compositions de prévention et traitement de maladies par administration d'acides nucléiques immunomodulateurs présentant une ou plusieurs séquences immunomodulatrice (IMSs), et sur des moyens et procédés d'identification des IMSs à des fins de prévention et de traitement de maladies, et plus particulièrement de maladies auto-immunes ou inflammatoires. L'invention porte également sur le traitement ou la prévention de maladies par administration d'acides nucléiques immunomodulateurs seuls ou associés à un polynucléotide codant pour des auto-protéines, auto-polypeptides ou auto-peptides. L'invention porte en outre sur des procédés et compositions de traitement de maladies d'un patient associées à une ou plusieurs auto-protéines, auto-polypeptides ou auto-peptides présents dans le patient mais intervenant à l'état non physiologique.
Garren Hideki
Ho Peggy P.
Steinman Lawrence
Bayhill Therapeutics Inc.
Smart & Biggar
The Board Of Trustees Of The Leland Stanford Junior University
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