C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) C07D 295/155 (2006.01)
Patent
CA 2610193
The invention relates to new processes for the manufacture of N-{5-[4-(4- methyl-piperazino- methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2- pyrimidine-amine of formula (I), new processes for the manufacture of metabolites of N-{5-[4-(4-methyl-piperazino-methyl)- benzoylamido]-2- methylphenyl}-4-(3-pyridyl)-2-pyrimidine-amine observed after administration of the compound to warm-blooded animals as well as to intermediates used in said processes. New starting materials as well as processes for the preparation thereof are likewise the subject of this invention. The processes described herein are especially suitable to furnish said compounds having isotopic labeling. The such obtained labeled compounds are in particular suitable to track and to investigate into the metabolism of N-{5-[4-(4-methyl- piperazino-methyl)-benzoylamido]-2-methylphenyl}-4-(3-pyridyl)-2-pyrimidine- amine and its pharmaceutically acceptable salts in clinical and pre-clinical studies.
L'invention concerne des procédés de fabrication de N-{5-[4-(4-méthyl-pipérazino- méthyl)-benzoylamido]-2-méthylphényl}-4-(3-pyridyl)-2-pyrimidine-amine de formule (I), des procédés de fabrication de métabolites de N-{5-[4-(4-méthyl-pipérazino-méthyl)- benzoylamido]-2-méthylphényl}-4-(3-pyridyl)-2-pyrimidine-amine observées après l'administration du composé à des animaux à sang chaud, ainis que des intermédiaires utilisés dans ces procédés. L'invention concerne, en outre, les produits de départ et les procédés de préparation de ceux-ci. Les procédés selon l'invention sont spécialement conçus pour fournir les composés possédant un étiquetage isotope. Les composés étiquetés ainsi obtenus sont spécialement conçus pour suivre et surveiller le métabolisme de N-{5-[4-(4-méthyl- pipérazino-méthyl)-benzoylamido]-2-méthylphényl}-4-(3-pyridyl)-2-pyrimidine-amine et ses sels acceptables sur le plan pharmaceutique dans des études cliniques et pré-cliniques.
Andres Hendrik
Bordeaux Kirk
Moenius Thomas
Rodriguez Perez Maria Ines
Salter Rhys
Fetherstonhaugh & Co.
Novartis Ag
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