Methods and kits for detecting mutations

Details Methods and kits for detecting mutations Methods and kits for detecting mutations

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) C12N 1/20 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2584784

Disclosed are methods and kits for detecting mutations in DNA by comparing the size of an amplified microsatellite locus to the expected size. The methods and kits may used in various applications, including monitoring exposure of a cell or organism to a mutagen, evaluating the mutagenicity of an agent, and evaluating a putative precancerous or cancerous cell or tumor cell for microsatellite instability.

L'invention concerne des procédés et des trousses permettant de détecter des mutations de l'ADN en comparant la taille d'un locus microsatellitaire amplifié avec la taille théorique de celui-ci. Ces procédés et ces trousses conviennent pour diverses applications, notamment la surveillance de l'exposition d'une cellule ou d'un organisme à un mutagène, l'évaluation de la mutagénicité d'un agent, et l'évaluation de l'instabilité microsatellitaire dans une cellule potentiellement précancéreuse ou cancéreuse, ou dans une cellule tumorale.

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