Methods and kits for expanding hematopoietic stem cells

Details Methods and kits for expanding hematopoietic stem cells Methods and kits for expanding hematopoietic stem cells

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) C12N 5/0789 (2010.01) C12N 15/00 (2006.01) C12N 15/67 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01)

Patent

CA 2636876

A method of increasing the expansion and/or differentiation of a hematopoietic stem cell (HSC) comprising: (a) increasing the level and/or activity of a polypeptide encoded by at least one gene selected from trim27, xbp1, sox4, smarcc1, sfpi1, fos, hmgb1, hnrpdl, vps72, tcfec, klf10, zfp472, ap2a2, gpsm2, gpx3, erdr1, tmod1, cnbp1, prdm16, hdac1, pml and ski, or a functional variant of said polypeptide, in said cell; (b) increasing the level of a nucleic acid encoding the polypeptide or functional variant of (a) in said cell; or (c) any combination of (a) and (b).

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