C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2406463
A method for the identification of foetal cell nuclei, chromosomes or DNA in a maternal blood or vaginal sample, said method comprising: a) subjecting chromosomes of cell nuclei in said sample to exonucleolytic digestion by an enzyme so as to remove end regions of each chromosome; and b) detecting the presence of a DNA sequence remaining in foetal DNA but absent from maternal DNA as a result of said digestion process. Once identified, the foetal DNA can be subject to diagnosis for example to detect chromosomal abnormalities.
L'invention concerne un procédé permettant l'identification de noyaux de cellules foetales, de chromosomes ou d'ADN dans le sang maternel ou un échantillon vaginal. Ce procédé consiste à : a) soumettre les chromosomes des noyaux de cellules dans ledit échantillon à une digestion exonucléolytique au moyen d'une enzyme, de manière à retirer les zones terminales de chaque chromosome; b) détecter la présence d'une séquence ADN restante dans l'ADN foetal mais absente de l'ADN maternel, en conséquence dudit processus de digestion. Une fois identifié, l'ADN foetal peut être soumis à un diagnostic, en vue de détecter des anormalités chromosomiques par exemple.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Btg International Limited
Simeg Limited
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