Methods and materials for expression of human plasminogen...

Details Methods and materials for expression of human plasminogen... Methods and materials for expression of human plasminogen...

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 38/48 (2006.01) A61K 38/54 (2006.01) C07K 14/315 (2006.01) C12N 9/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2072649

A cleavage-resistant plasminogen molecule is provided that is conveniently produced in recombinant cells by expression of a nucleic acid sequence encoding the plasminogen molecule. Preferably the plasminogen is a sequence variant with a modifica- tion in its two-chain cleavage site. The plasminogen molecule may be purified, acylated, complexed with acylated or non-acylated fibrinolytic enzymes, and formulated into pharmaceutical compositions for use in thrombolytic therapy.

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