C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/10 (2006.01) A61K 38/16 (2006.01) C07K 14/16 (2006.01) C07K 14/47 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2374180
The present invention relates to controlled modification of Src homology region 3 (SH3) domains by using random manipulation of the non-conserved region of SH3 RT-loop. Consequently, the invention concerns methods and materials for generating SH3 domains with engineered binding properties, and their use as tools in research, diagnostics, therapy and drug discovery.
La présente invention concerne la modification contrôlée des domaines (SH3) de région 3 à homologie Src au moyen d'une manipulation aléatoire de la région non conservée de la boucle SH3 RT. Par conséquent cette invention concerne des procédés et des matériaux utiles pour générer des domaines SH3 ayant des propriétés de liaison obtenues par manipulation, et leur utilisation en tant qu'outils dans le cadre du diagnostic de recherche, de la thérapie et de la découverte de médicaments.
Hiipakka Marita
Saksela Kalle
Mccarthy Tetrault Llp
Next Biomed Technologies Nbt Oy
Saksela Kalle
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