Methods and materials for preparation of modified antibody...

Details Methods and materials for preparation of modified antibody... Methods and materials for preparation of modified antibody...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 1/107 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) C12P 21/08 (2006.01) A61K 38/00 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2103887

Methods are described for identifying the amino acid residues of an antibody variable domain which may be modified without diminishing the native affinity of the domain for antigen while reducing its immunogenicity with respect to a heterologous species and for preparing so modified antibody variable domains which are useful for administration to heterologous species. Antibody variable regions prepared by the methods of the invention are also described.

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