C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 31/7088 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61P 29/00 (2006.01) C07K 14/195 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/31 (2006.01)
Patent
CA 2508302
The invention provides methods and materials for treating inflammatory conditions. Specifically, the invention provides polypeptides, isolated nucleic acids, host cells, and methods that can be used to induce an antibody response in a mammal against an antigen such as C5 or C5a. For example, the methods and materials described herein can be used to reduce the effects of C5a within a mammal by reducing the amount of total and receptor bound C5a in the mammal.
La présente invention concerne des techniques et des matériaux de traitement d'états inflammatoires. Plus précisément, cette invention concerne des polypeptides, des acides nucléiques isolés, des cellules hôtes et des techniques qu'on peut utiliser pour induire une réponse d'anticorps chez un mammifère dirigée contre un antigène tel que C5 ou C5a. On peut utiliser, par exemple, ces techniques et ces matériaux pour réduire la quantité totale de C5a et de C5a liés au récepteur chez un mammifère.
Hellman Lars T.
Holmdahl Rikard
Resistentia Pharmaceuticals Ab
Sim & Mcburney
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