C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C07K 5/00 (2006.01) C07K 14/47 (2006.01) C07K 14/81 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C12N 9/16 (2006.01) C12N 9/64 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2399681
The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted alpha-2-macroglobulin-like polypeptides. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from fetal brain mRNA (Clontech) (SEQ ID NO: 1) and uterus mRNA (Clontech) (SEQ ID NO: 26). Other aspects of the invention include vectors containing processes for producing novel human secreted alpha-2-macroglobulin-like polypeptides, and antibodies specific for such polypeptides.
Cette invention concerne des polynucléotides et des polypeptides codés par de tels polynucléotides ainsi que leurs mutants et des variants, qui correspondent à de nouveaux polypeptides humains sécrétés de type alpha-2-macroglobuline. Ces polynucléotides renferment des séquences d'acides nucléiques isolées à partir d'une librairie d'ADNc tirée d'un ARNm de cerveau foetal (Clontech) (SEQ ID NO: 1) et d'un ARNm utérin (Clontech) (SEQ ID NO: 26). D'autres aspects de l'invention concerne des vecteurs renfermant des processus permettant de produire des polypeptides humains sécrétés de type alpha-2-macroglobuline, ainsi que des anticorps spécifiques de tels polypeptides.
Arterburn Matthew C.
Boyle Bryan J.
Deng Cenhua
Drmanac Radoje T.
Godbole Shubhada D.
Hyseq Inc.
Nuvelo Inc.
Smart & Biggar
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