Methods and materials relating to fibulin-like polypeptides...

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/00 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C07K 14/78 (2006.01) C07K 17/00 (2006.01) C12N 1/00 (2006.01) C12N 1/22 (2006.01) C12P 19/34 (2006.01) C12P 21/06 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01) C07B 61/00 (2006.01)

Patent

CA 2441006

The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted fibulin-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from a cDNA library prepared from human thyroid gland mRNA (Clontech) (SEQ ID NO: 1). Other aspects of the invention include vectors containing processes for producing novel human secreted fibulin-like polypeptides, and antibodies specific for such polypeptides.

Cette invention concerne de nouveaux polynucléotides, ainsi que des polypeptides codés par ces polynucléotides, et leurs mutants ou variants, qui correspondent à un nouveau polypeptide humain sécrété apparenté à la fibuline. Ces polynucléotides comprennent des séquences d'acide nucléique isolées d'une bibliothèque d'ADNc préparée à partir de l'ARNm de la glande thyroïde humaine (Clontech) (SEQ ID NO: 1). D'autres aspects de l'invention incluent des vecteurs contenant des processus destinés à produire de nouveaux polypeptides humains sécrétés apparentés à la fibuline, et des anticorps spécifiques desdits polypeptides.

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