C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/00 (2006.01) C07H 21/02 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C12N 9/16 (2006.01) C12N 9/64 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2398251
The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted leukocyte immunoglobulin receptor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from a cDNA library prepared from human leukocyte mRNA (GIBCO Laboratories) (SEQ ID NO: 1, SEQ ID NO: 16); from infant brain mRNA (Columbia University) (SEQ ID NO: 35); from human mammary gland mRNA (Invitrogen) (SEQ ID NO: 47); and from bone marrow mRNA (Clontech) (SEQ ID NO: 63). Other aspects of the invention include vectors containing processes for producing novel human secreted LIR-like polypeptides, and antibodies specific for such polypeptides.
L'invention concerne des nouveaux polynucléotides et polypeptides codés par de tels polynucléotides ainsi que leurs mutants ou variants qui correspondent à un nouveau polypeptide humain sécrété semblable à un récepteur de leucocyte de type immunoglobuline. Ces polynucléotides renferment des séquences d'acide nucléique isolées de banques d'cADN préparées à partir d'une banque d'cADN préparée à partir d'un mARN de leucocyte humain (Laboratoires GIBCO) (SEQ ID NO:1, SEQ ID NO:16); d'un mARN du cerveau d'un nourrisson (Columbia University) (SEQ ID NO: 35); d'un mARN de glande mammaire humaine (Invitrogène) (SEQ ID NO: 47); et d'un mARN de moelle osseuse (Clontech) (SEQ ID NO: 63). D'autres aspects de l'invention concernent des vecteurs contenant des procédés de production de polypeptides humains sécrétés semblables à LIR, ainsi que des anticorps propres à de tels polypeptides.
Arterburn Matthew C.
Asundi Vinod
Boyle Bryan J.
Drmanac Radoje T.
Haley-Vicente Dana
Hyseq Inc.
Nuvelo Inc.
Smart & Biggar
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