C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/18 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 5/00 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C12N 9/16 (2006.01) C12N 9/64 (2006.01) C12P 19/34 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2399652
The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted NGM-like polypeptides. These polynucleotides comprise nucleic acid sequences isolated from at least cDNA libraries prepared from adult spleen mRNA (GIBCO) (Hyseq clone identification numbers 3073928 (SEQ ID NO: 1), and from infant brain mRNA (Columbia University) (Hyseq clone identification number 6346549) (SEQ ID NO: 18). Other aspects of the invention include vectors containing processes for producing novel human secreted NGM-like polypeptides, and antibodies specific for such polypeptides.
L'invention concerne de nouveaux polynucléotides et les polypeptides codés par ces derniers, ainsi que des mutants et des variants de ces derniers qui correspondent à de nouveaux polynucléotides humains sécrétés du type NGM. Ces polynucléotides renferment des séquences d'acides nucléiques isolées de banques d'ADNc, préparées à partir d'ARNm de rate humaine (GIBCO) (numéro d'identification de clone Hyseq 3073928 (SEQ ID NO: 1), et à partir d'ARNm d'un cerveau de bébé (Columbia University) (numéro d'identification de clone Hyseq 6346549) (SEQ ID NO: 18). Dans d'autres modes de réalisation, l'invention concerne des vecteurs contenant des processus de production de nouveaux polynucléotides humains sécrétés du type NGM, et les anticorps spécifiques à ces polypeptides.
Arterburn Matthew C.
Boyle Bryan J.
Drmanac Radoje T.
Godbole Shubhada D.
Kuo Chiaoyun
Hyseq Inc.
Nuvelo Inc.
Smart & Biggar
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