C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) C07K 14/475 (2006.01) C07K 16/22 (2006.01) C12N 5/10 (2006.01) C12N 15/22 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2405104
The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human stem cell growth factor-like protein. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human testis cells (Hyseq clone identification numbers 2880984 and 2881695, from human fetal skin (Hyseq clone identification number 15375176), adult spleen (Hyseq clone identification number 14856094), and human endothelial cells (Hyseq clone identification numbers 13804756, 13687487, 13804756). Other aspects of the invention include vectors containing processes for producing novel human stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.
L'invention concerne de nouveaux polynucl~otides et polypeptides cod~s par ces polynucl~otides et des mutants ou variants de ceux-ci qui correspondent ~ un nouveau polypeptide s~cr~t~ humain du type facteur de croissance de cellules souches. Ces polynucl~otides comprennent des s~quences d'acide nucl~ique isol~es ~ partir de bibliothques d'ADNc pr~par~es ~ partir de cellules de testicules humains (num~ros d'identification de clone Hyseq 2880984 et 2881695), de peau de foetus humains (num~ro d'identification de clone Hyseq 15375176), de rates d'adulte (num~ro d'identification de clone Hyseq 14856094) et de cellules endoth~liales humaines (num~ros d'identification de clone Hyseq 13804756, 13687487, 13804756). D'autres aspects de l'invention concernent des vecteurs contenant des processus pour produire de nouveaux polypeptides humains du type facteur de croissance de cellules souches, ainsi que des anticorps sp~cifiques de ces polypeptides.
Chao Cheng-Chi
Drmanac Radoje T.
Labat Ivan
Mize Nancy K.
Nishikawa Mitsuo
Chao Cheng-Chi
Drmanac Radoje T.
Kirin Beer Kabushiki Kaisha
Labat Ivan
Mize Nancy K.
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