Methods and materials relating to stem cell growth...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/63 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2395443

The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted stem cell growth factor-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries prepared from human fetal liver spleen, ovary, adult brain, lung tumor, spinal cord, cervix, ovary, endothelial cells, umbilical cord, lymphocyte, lung fibroblast, fetal brain, and testis. Other aspects of the invention include vectors containing processes for producing novel human secreted stem cell growth factor-like polypeptides, and antibodies specific for such polypeptides.

Cette invention se rapporte à de nouveaux polynucléotides et à des polypeptides codés par ces polynucléotides et à des mutants ou variants de ceux-ci qui correspondent à un nouveau polypeptide sécrété humain du type facteur de croissance de cellules souches. Ces polynucléotides comprennent des séquences d'acide nucléique isolées à partir de bibliothèques d'ADNc préparées à partir d'organismes humains, notamment à partir de foies/rates de foetus, d'ovaires, de cerveaux d'adultes, de tumeurs des poumons, de moelle épinière, de glaire cervicale, d'ovaires, de cellules endothéliales, de cordon ombilical, de lymphocytes, de fibroblastes de poumons, de cerveaux de foetus et de testicules. D'autres aspects de cette invention concerne des vecteurs contenant des processus pour produire de nouveaux polypeptides sécrétés humains du type facteur de croissance de cellules souches, et des anticorps spécifiques de ces polypeptides.

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