Methods and means for diagnostics, prevention and treatment...

A - Human Necessities – 61 – K

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A61K 39/04 (2006.01)

Patent

CA 2603356

The invention identifies a narrow subset of Mycobacterium latency associated antigens and/or epitopes that are capable of eliciting an immune response in vivo and and in vitro in a mammal. The invention provides methods and compositions for detection and immunization against latent Mycobacterium infections. These compositions comprise those Mycobacterial latency antigens that are actually capable of eliciting an immune response in vivo, in mammals experiencing a latent Mycobacterium infection. More preferably the compositions comprise those antigens that are preferentially recognized by latently infected individuals and which antigens are not, or to a much lesser extent, recognized in individuals having an active Mycobacterium infection or in individuals having Mycobacterium induced symptoms or diseases, such as in patients infected with M. tuberculosis suffering from tuberculosis disease (TB).

Cette invention concerne un sous-ensemble étroit d'antigènes et/ou d'isotopes associés à la latence de Mycobacterium capables de déclencher une réponse immunitaire in vivo et in vitro chez un mammifère. Cette invention concerne également des procédés et des compositions permettant de détecter les infections à Mycobacterium latentes et d'immuniser contre de telles infections. Les compositions décrites dans cette invention comprennent les antigènes associés à la latence de mycobactéries, lesquels antigènes sont capables de déclencher une réponse immunitaire in vivo, chez des mammifères souffrant d'une infection à Mycobacterium latente. Plus avantageusement, les compositions décrites dans cette invention comprennent les antigènes qui sont, de préférence, reconnus par des individus infectés de manière latente; ces antigènes ne sont pas reconnus, ou très peu, chez des individus souffrant d'une infection à Mycobacterium active ou chez des individus présentant des symptômes ou des maladies induites par Mycobacterium, tel que chez des patients infectés par la M. tuberculosis souffrant de tuberculose (TB).

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