C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/00 (2006.01) A01H 3/00 (2006.01) A01H 4/00 (2006.01) A01H 5/00 (2006.01) C12N 15/29 (2006.01) C12N 15/82 (2006.01)
Patent
CA 2330933
Rice, wheat and other monocotyledonous plants are transformed with expression cassettes for production of mammalian polypeptides, such as antibodies. Endoplasmic reticulum (ER) retention signals, 5'untranslated regions and leader peptides are employed in various combinations to provide high expression yield. Multi-chain complexes such as four-chain secretory antibodies are produced by expression of component polypeptides from separate vectors all introduced into the same cell by transformation.
Du riz, du blé et d'autres plantes monocotylédones sont transformées à l'aide de cassettes d'expression pour la production de polypeptides de mammifères, tels que des anticorps. Des signaux de retenue du réticulum endoplasmique (ER), des régions non traduites 5' et des peptides leaders sont employés dans diverses combinaisons pour fournir un fort rendement d'expression. Des complexes à chaînes multiples tels que des anticorps de sécrétion à quatre chaînes sont produits par l'expression de polypeptides constituants provenant de vecteurs séparés tous introduits dans la même cellule par transformation.
Christou Paul
Fischer Rainer
Ma Julian K.-C.
Martin-Vaquero Carmen
Schillberg Stefan
Fischer Rainer
John Innes Centre
King's College London
Martin-Vaquero Carmen
Mcfadden Fincham
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