Methods and means for extracorporeal organ perfusion

Details Methods and means for extracorporeal organ perfusion Methods and means for extracorporeal organ perfusion

A - Human Necessities

01

N

A01N 1/02 (2006.01)

Patent

CA 2369159

Apparatus and methods of operation of apparatus for the extracorporeal perfusion of organs are provided which support viability and function of an organ such as a liver, generally outside the body. Blood is supplied as described herein to an organ such as a liver under physiological pressure but without forcing blood flow at any particular rate such that the organ is allowed to auto-regulate blood flow. This allows for organ preservation or resuscitation prior to transplantation, maintenance of organs for use in experimental study of isolated liver physiology, and treatment of patients suffering from organ failure.

L'invention concerne un dispositif de perfusion extracorporelle d'organes et des procédés d'utilisation de ce dispositif permettant de soutenir la viabilité et la fonction d'un organe tel que le foie, en général à l'extérieur du corps. On apporte du sang à un organe, par exemple le foie, conformément au mode décrit, à une pression physiologique mais sans forcer le sang à circuler à un débit particulier, de manière à permettre l'autorégulation du débit sanguin par l'organe. Ce dispositif permet ainsi la conservation ou la restauration de l'organe avant une transplantation, l'entretien des organes utilisés dans des études expérimentales de la physiologie du foie isolé, et le traitement de patients souffrant d'une insuffisance d'un organe.

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