Methods and means for monitoring and modulating gene silencing

Details Methods and means for monitoring and modulating gene silencing Methods and means for monitoring and modulating gene silencing

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) C12N 15/82 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2478910

Methods and means are provided for monitoring and modulating reduction of gene expression in eukaryotic organisms, using double stranded RNA comprising, in addition to the dsRNA region comprising nucleotide sequences homologous to the target gene, additional dsRNA regions designed to down.

L'invention concerne des méthodes et des moyens de surveillance et de modulation de la réduction de l'expression génique dans des organismes eucaryotes, à l'aide d'un ARN bicaténaire comprenant, en plus de la région d'ARN bicaténaire contenant des séquences nucléotidiques homologues au gène cible, des régions d'ARN bicaténaire supplémentaires destinées à être réduites.

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