Methods and means for producing glycoproteins with altered...

Details Methods and means for producing glycoproteins with altered... Methods and means for producing glycoproteins with altered...

C - Chemistry, Metallurgy

12

N

C12N 15/82 (2006.01) C07K 14/415 (2006.01)

Patent

CA 2687605

The invention provides methods to modify the N-glycosylation pattern of glycoproteins in higher plant cells, through reducing or eliminating the level of .beta.(1,2) xylosyltransferase and .alpha. (1,3) fucosyltransferase activity and increasing the .beta.(1,4)galactosyltransferase activity in the cell of the higher plant.

La présente invention concerne des procédés permettant de modifier le motif de N-glycosylation des glycoprotéines dans les cellules de végétaux supérieurs, par la réduction ou l'élimination du niveau d'activité de la .beta.(1,2) xylosyltransférase et de la .alpha. (1,3) fucosyltransférase et par l'augmentation de l'activité de la .beta.(1,4)galactosyltransférase dans la cellule du végétal supérieur.

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